(Albany, United States) As per DelveInsight’s assessment, globally, the PCSK9 Inhibitor Pipeline constitutes 14+ key companies continuously working towards developing 14+ PCSK9 Inhibitor Pipeline treatment therapies, analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments analysis DelveInsight.
In the PCSK9 Inhibitor Pipeline Report, a detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, PCSK9 Inhibitor NDA approvals (if any), and product development activities comprising the technology, PCSK9 Inhibitor collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
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Key Takeaways from the PCSK9 Inhibitor Pipeline Report
PCSK9 Inhibitor Overview
Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) is a serine protease involved in cholesterol homeostasis. After binding to the complex low-density lipoprotein (LDL)-receptor, PCSK9 induces its intracellular degradation, thus reducing serum LDL clearance.
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PCSK9 Inhibitor Emerging Drugs Profile
Evolocumab (Repatha) is a monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9). It is being investigated for the treatment of patients with high-risk cardiovascular disease without prior heart attack or stroke. It is being investigated for the treatment of familial hypercholesterolemia in pediatric patients.
ION449 (formerly IONIS-AZ4-2.5-LRx), also known as AZD8233, is a ligand-conjugated (LICA) investigational antisense medicine designed to reduce plasma levels of proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 is integrally involved in the regulation of LDL-cholesterol. Genetic studies have shown that individuals with life-long reduction of LDL-C due to reduced function of PCSK9 have substantially reduced risk of cardiovascular disease. Pharmacological inhibition of PCSK9 substantially lowers LDL-C. ION449 is designed to reduce the liver production of PCSK9 and lower the plasma level of LDL-C and thus reduce the risk of cardiovascular disease.
PCSK9 Inhibitor Therapeutics Assessment
There are approx. 14+ key companies which are developing the therapies for Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor. The PCSK9 Inhibitor companies which have their Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor drug candidates in the most advanced stage, i.e. Phase III include, Amgen.
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PCSK9 Inhibitor Drugs and Companies
Some of the Companies in the PCSK9 Inhibitor Therapeutics Market include-
Ionis Pharmaceuticals, Akeso Biopharma, Amgen, Novo Nordisk, Civi BioPharma, and others.
Dive deep into rich insights for drugs for PCSK9 Inhibitor Pipeline, click here @ PCSK9 Inhibitor Unmet Needs and Analyst Views
Scope of the PCSK9 Inhibitor Pipeline Report
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